小川 秀一郎
（おがわ・しゅういちろう）
Shuichiro Ogawa
略歴
- 熊本大学医療技術短期大学部 衛生技術学科卒業（臨床検査技師免許取得）
- 九州大学大学院医学系学府保健学専攻 検査技術科学分野 修士課程修了
- 京都大学博士（医学）、京都大学医学部博士研究員、京都保健衛生専門学校専任教員 (臨床検査学科)を経て本学へ着任。
免疫内分泌学研究室
卒業研究テーマ例
- 下垂体由来ホルモンACTHの分泌制御機構を修飾する因子の探索
- 自然炎症に関わるマクロファージの表現型解析
- Reck発現細胞の細胞生物学的分類
下垂体由来ホルモンの分泌制御機構に関する研究
自然炎症が下垂体細胞に与える影響に関する研究
マウス視床下部および他の臓器に分布するReck発現細胞の細胞生物学的解析
- 研究の応用領域
- 内分泌疾患の診断/治療に有用な診断薬/検査機器/治療薬の開発
- 産官学連携で求めるパートナー
- 検査機器・診断薬関連企業
Studies on the mechanisms of pituitary gland-derived hormone secretion
The pituitary gland functions in vertebrates, from fish to mammals, as an central endocrine organ that produces various hormones, including growth hormone and prolactin. ACTH (adrenocorticotropic hormone) is among of anterior pituitary, and acts on the adrenal cortex to promote the secretion of cortisol. Immune checkpoint inhibitors (e.g. nivolumab), which have recently been used in cancer treatment, have a clinical problem in that they induce various irAEs (immune-related adverse events), such as isolated ACTH deficiency, but methods to avoid irAEs have not yet been developed. Therefore, we are searching for immunological factors that can induce irAEs, especially factors that affect ACTH secretion, using the mouse pituitary ACTH-producing cell line AtT-20.
Study on the effects of natural inflammatory mechanisms on pituitary cells
One of the immunological factors we will explore in the above-mentioned project is LPS (lipopolysaccharide) derived from gram-negative bacteria. LPS acts as a ligand for TLR4 (Toll-like receptor) and promotes the secretion of inflammatory cytokines from phagocytes such as macrophages. We are analyzing the changes in gene/protein levels when LPS is applied to mouse monocytic cell line J774.1 and an inflammatory state is induced. In particular, we aim to explore factors that cause specific inflammation in the pituitary gland.
Cell biological analysis of Reck-expressing cells in the mouse hypothalamus and other organs
Reck (Reversion-inducing Cysteine rich protein with Kazal motifs) is a protein that inhibits the activity of MMP (matrix metalloproteinase), and its expression is reduced in many cancer cells. Although a limited distribution of Reck-expressing cells has been found in the mouse hypothalamus (DOI: 10.1016/j.mce.2020.110790), the cell type is unclear, so we are working to identify the cell type using immunohistochemistry and other techniques. In addition, since Reck plays an important role in angiogenesis (DOI: 10.1038/srep17860), we are conducting collaborative research with overseas laboratories to elucidate the distribution and physiological significance of Reck-expressing cells in the cardiovascular system.
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Tomoko Matsuzaki, Huan Wang, Yokio Imamura, Shunya Kondo, Shuichiro Ogawa, Makoto Noda. Generation and characterization of a mouse line carrying Reck-CreERT2 knock-in allele. Genesis 56;e23099, 2018.
Glicia Maria de Almeida, Mako Yamamoto, Yoko Morioka, Shuichiro Ogawa, Tomoko Matsuzaki, Makoto Noda. Critical roles of for murine Reck in the regulation of the vascular patterning and stabilization. Scientific Reports 5:17860, 2015.
Kenichi Izumi, Keiichiro Mine, Yoshitaka Inoue, Miho Teshima, Shuichiro Ogawa, Yuji Kai, Toshibobu Kurafuji, Kanako Hirakawa, Daiki Miyakawa, Haruka Ikeda, Akari Inada, Manami Hara, Hisakata Yamada, Koichi Akashi, Yoshiyuki Niho, Keisuke Ina, Takashi Kobayashi, Yasunobu Yoshikai, Keizo Anzai, Teruo Yamashita, Hiroko Minagawa, Shuji Fujimoto, Hironori Kurisaki, Kazuya Shimoda, Hitoshi Katsuta, Seiho Nagafuchi. Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes. Nature Communications 6:6748, 2015.