大橋 英治
（おおはし・えいじ）
Eiji Ohashi
略歴
- 京都大学大学院理学研究科博士後期課程修了
- 京都大学ウイルス研究所（現・医⽣物学研究所）助手、米国立衛生研究所Visiting Fellow、九州大学大学院理学研究院生物科学部門助教、同講師を経て本学へ
DNA損傷応答機構の解明とその利用
- 研究の応用領域
- 抗がん剤、化学物質検出キットの開発
- 産官学連携で求めるパートナー
- 大学、国・地方自治体の研究機関、医療関連の企業
Comprehensive understanding of molecular mechanisms of DNA damage response and its application
The genetic material of living organisms, DNA is constantly damaged by various factors. Cells have a series of mechanisms to detect DNA damage, transduce the signal, and repair damaged DNA. Dozens of proteins and their interaction play important roles in these and related reactions. I have contributed to the understanding of the mechanisms by which specialized DNA polymerases bypass DNA damage and the mechanisms by which cells activate DNA damage checkpoint pathways. In collaboration with other researchers, I will try to more comprehensively elucidate these mechanisms to develop anticancer drugs and kits for detection of DNA-damaging chemicals.
Ohashi E, Tsurimoto T. (2017) Functions of multiple clamp and clamp-loader complexes in Eukaryotic DNA replication. Adv. Exp. Med. Biol. 1042: 135-162
Ohashi E, Takeishi Y, Ueda S, Tsurimoto T. (2014) Interaction between Rad9-Hus1-Rad1 and TopBP1 activates ATR-ATRIP and promotes TopBP1 recruitment to sites of UV-damage. DNA Repair 21: 1-11
Ohashi E, Hanafusa T, Kamei K, Song I, Tomida J, Hashimoto H, Vaziri C, Ohmori H. (2009) Identification of a novel REV1-interacting motif necessary for DNA polymerase κ function. Genes Cells 14: 101-111
Ohashi E, Murakumo Y, Kanjo N, Akagi J, Masutani C, Hanaoka F, Ohmori H. (2004) Interaction of hREV1 with three human Y-family DNA polymerases. Genes Cells 9: 523-531
Ohashi E, Ogi T, Kusumoto R, Iwai S, Masutani C, Hanaoka F, Ohmori H. (2000) Error-prone bypass of certain DNA lesions by the human DNA polymerase κ. Genes Dev. 14: 1589-1594